IF the stock fits me and IF the gun is not too light I find I do pretty well up to the 505 Gibbs
I like the 416 Taylor, 404 Jeffery and 375 H&H about the best of them all, because they work REALLY WELL on game, and they don't hurt me at all to shoot. I can shoot bigger, and shoot them well, but I see no reason to.
In muzzleloaders, I LIKE the 8 bore. Bigger is too much for me.
I won't fire the 4s anymore, and I am going to make a 2 bore for a gentleman soon, but I won't even think about firing it. That's going to be his job.