I have shot both and based on my experience I would choose the 375 H&H over the Weatherby for a variety of reasons..

First of all, you do NOT need that kind of velocity for what you will be hunting.. in Africa, most shots are relatively close --even plains game--I have taken 56 animals to date in Africa and my longest shot so far was on a gemsbok which was about 225.. easily within the limits of a .375..

If I was hunting plains game I would use the 270 bullets--and 300 if dangerous game.. but a premium bullet none the less..

Recoil is dramatically increased from the H&H to the Weatherby..

Ammo is much more readily available around the world for the H&H..

Less recoil, less chance of potential problems with scopes..

As the Weatherby is a proprietary cartridge, unless you buy a gun and yank the barrel for a new one you choiced of firearms chambered in that caliber will be somewhat limited.

I must admit, I am a speed demon when it comes to bolt action cartridges, I have 2 rifles chambered for .257 Weatherby,, with 26" barrels --shooting 100 gr TSX--they chronographed at 3800 plus fps.. the effect on game here in Montana is amazing --however when you kick up to that kind of velocity you really need to choose your bullets carefully.. I am also shooting all the Ultra-mag calibers in one brand of rifle or another--my 300 ultra is in a HS Precision -and there again .. I needed to move a well construted bullet.. 180 gr A-Frames at 3420 fps..

My point in all of this is, that after going to Africa and shooting guns in the 2400 fps to 2700 fps range.. It changed my attitude on speed, realizing that it is not that critical--fun, yes,, necessary, no..

Get the H&H and never look back--it will be a great gun..

thx,

Ripp