500 Nitro - makes little or no difference in feel for a practised shooter.
: My ZKK's in .358 and .375, in the field feel little different than my more common 98 Mausers. You pull the bolt back, it stops, then you push it forward to chamber a round - 1 fluid motion back and forward.
: Most .375's have a bit of extra beef to them, welcomed by most, but over the years, there's been a steady push for lighter guns. Perhaps the .375 Ruger will appeal to those people. If I were to build one, it would be a normal 9-1/2 or 10 pounds with scope. My BRNO .375, at 11 pounds, loaded & with scope felt just fine, but nowadays, I do prefer the feel of a 9 1/2 pounder. That's where BoydBoys stocks come in. I would not build one on a synthetic stock.