khornet,

Welcome don't worry about not being able to type or spell. Getting your point across is what is important.

The short answer is not, not at least with a single bullet. Buffalo and Elephants are much, much tougher than any Deer. They are also much, much larger.

One of the reasons, there are many, for carrying a large caliber is for the shot that you can't plan for. An unexpected shot or even a charge. To rely on the skill and ability of any PH is foolish. It's your life and body, not his.