I have to agree with the suggestion of a .375 H&H as the "all-around" caliber for big game hunting - in the USA or in Africa.

Mine is a customized BRNO ZKK 602. It holds 5 in the mag and 1 in the chamber, which is more than enough for any game here I'm likely to hunt. If 6 rds of 375 H&H aren't sufficient to stop something in Africa, then your PH will be touching his gun off.

The 375 can, and has, been used successfully on Buffalo, but in everything I've read it's reported to be the legal minimum, and some PHs would prefer to see a larger caliber IF you can handle it.

Anyway, you have plenty of rifle options in the venerable old .375 H&H. I chose a BRNO 602 after reading up on it and researching how it might be customized to be more user-friendly. One was available locally NIB, so I jumped on it and didn't look back.

I shoot factory .375 loads as well as handload for it. Mine's proven very accurate.

Good luck finding your big game rifle.