Hello Gentlemen,
I just wanted to chime in with my opinion. I have to agree with 500 grains, he pretty well wrapped everything up into a nice neat little package. ( Great website link, by the way). Although I don't have his experience hunting DG, I have to echo his sentiments about my model 70 . I've spent about $600 tuning my .375 into something I'm comfortable taking on my first safari.
Best Regards... Sean