I have used a 225 gr 338 nosler partition on bear with good results shooting thru a shoulder bone to the lungs. The bear dropped, then ran 75 yards and died.

There is no doubt that other bullets would work as well but I think a 260 gr nosler partition in a 375 cal would be more than adequate if driven at an adequate velocity. The boney structure of a bear is heavy and decent penetration is a must.

Have a great hunt!!