Hydrostatic shock with the big bore-

Doesn't that start to happen somewhere above 2400fps?
I've seen loads for the 250gr BarnesX up past 2700fps, that'd be misty puffclouds outta whatever barnyard varmint comes your way via the .458winmag.

Whooogolly!
I think you could vaporize the better part of a coyote's midsection with that kind of load, it'd completely dissappear a skunk or raccoon.

--Tinker