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303, I only shot the "Poor man's buffalo" with my #1 last year, so I guess I'm poorly equipped to answer . Blue Wildebeest at @ 30 yards. I used a 400gr Woodleigh soft pushed to a bit over 2,000fps by Varget and it punched through the chest and downed the fellow after a brief 20 yard or so run. A white tail deer doe this fall was the second animal I've taken with that load. FWIW the 450-400 was supposed to launch 400gr bullets at 1,950 from the Tropical load and 2,150 fps for the normal load. You should be able to get the Woodleighs and Varget easier than I can. I've also loaded the 400gr Woodleigh solid to hit the same POI with a grain less powder than the soft load. The Hornady bullets didn't seem to hold up well when I shot them into water or mud, the Woodleigh's did well even after hitting dirt and rock. If the 300gr Woodleigh is a "Weld core" it might do pretty well too. Personally, I think a .405 double rifle regulated for that load would be a grand hunting tool. hth Rick |