The .375 is a Class I DG caliber. It is certainly sufficient for hunting dangerous game. It is the client hunter's first choice, especially for one who doesn't intend to spend six months slowly just getting used to the recoil of something larger. However, for stopping a charge something more potent is very desirable. Admittedly, stopping a charge is not, all puff and bluster from other members aside, the job of the client hunter. That's why 99% of all safaris have a PH along. He's the one who needs the Class III when things go south. For the rest of us, the .375 is Queen of Calibers.