I thought Phil Shoemaker's replies to Afrikaander's same questions over on Accurate Reloading might be of interest to eveyrone. Phil is a fairly well known brown bear guide in Alaska. Remember, he's taking about the new Hornady InterBonds and not the old InterLocks. The InterBonds are a bonded core bullet.

More info here on Hornady's web site:
Hornady InterBond Round Nose

458 Cal., 500 gr. InterBond RN
416 Cal., 400 gr. InterBond RN
375 Cal., 300 gr. InterBond RN

-Bob F.

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Phil's posts to Afrikaander from AR:

I tested both the .416 and .458 Hornady soft nosed bullets this past season and could not completely destroy them even by firing them into rock. I certainly would feel perfectly safe and secure using them on anything a soft nosed bullet is suitable for. In fact they may become a new favorite in .375, .416 and .458.
- Phil Shoemaker

I probably answered your question in another forum as well but from my experience the new Hornady Interbond in .416 is one of the best soft nosed bullets now avaliable and again, from my experience, will give deeper and more reliable penetration than the Woodleighs I have tried.
- Phil Shoemaker