Yes, Any of the 375 Woodleigh's will kill what
you want to hunt as long as you do your bit
with Bullet Placement.

Personally, go with 300gn RN or PP.

I've shot heaps of Buffalo with the 375H&H
and Woodleighs.

350 is a big long bullet and although good for
what it is designed for doesn't give you flat LONG range
trajectory.

If you have any more questions, just ask.

500 Nitro