Sure, these are all theoretical considerations, but I was still able to observe the better working at longer range on heaver game of a 250gr bullet caliber 338 compared to a 180gr bullet caliber 308. Therefore there is no reason that a 300gr bullet caliber 375 works even better, same requirements when it comes to bullet construction.

I have a good opinion of the cartridge 30-06 Springfield, but it has its limits when it comes to bullet weight and shooting distances.