When I was guiding, a .458 of some sort, either .458 American (400gr.Barnes @ 2,150fps), or the .458 Alaskan (.400gr. Barnes at 2,300fps) was my back-up rifle. Only needed the .458 2" once, on a black bear at very close range.

Hunting by myself for years, with the .458 2" or a .375 of one sort or another. Even used a .257 Ackley IMP on moose one fall.
If I go out hunting now, it's my 1936 Winchester .30GVT06. 180's at 2,745fps. I just love that rifle. The .375 stays in the lockup.