I like my 404, but it gets little use. I have one rifle that I think of as a "one-size-fits-all" and that's my 375H&H but I can confess that a very close runner-up is my 9.3X62.
The 404 does all I ever asked of it, but I never asked it to make kills at 200 to 450 yards. I am sure it would, but the 375 does too, and do so with less drop and less wind drift as well as less recoil.
The truth is that for every time I have been close enough to something big and felt I wanted a "heavier club" to strike it with I have killed about 200 animals that were at 50 yards to 150 yards and in all my years of using the 375H&H I can recall not 1 time I ever truly needed to shoot an animal 2 times. I have shot a few 2 times, but for insurance shots, not ever because I really needed to. I did the same with my 404 back in the 70s.

So as I have aged I found little use for my three 416s my four 458s and my 460. Because of that fact I sold them all. I kept a 404 for the reason of the wonderful memories associated with that cartridge (I used one like it for nearly a year back in the 70s) However my 375H&H is well into it's 2nd barrel. I shot that rifle so much I eroded the rifling out of the throat and needed a new barrel after about 20 years of constant us.

So I AM a true fan of the 404, but I don't think of it as mush as a rifle for every hunt and use.

But I would take my 375 for about anything I was going to hunt without any big reservations. From Rock Chucks and coyotes to buffalo, the 375 has worked for me and I never found it to lack substantially for any use I ever asked it to do. The closest thing I have found to it so far is the 9.3X62 but I have only been using my my 9.3s now for about 9 years so I don't have near the degree of experience with it I do with the 375 (46 years)