Only if your goal is to over expand the bullets, or shoot P-Dogs at 400 yds! The added velocity is not needed for hunting the animals the 375 H&H was designed for! It will give you about a two inch flatter trejectory at 300 yds over the old 375 H&H. I don't think I could see the difference in four inch, and a two inch object at 300 yds.

Addtionally, if Buffalo is your target for your CZ, then that two inch flatter trejectory is not worth it to me. Buffalo are dangerous game, and the whole idea in hunting him is, that he is dangerous! He is simply not dangerous at 300 yds., defeating the purpose of uping the speed a little to get the extra flatness of two inches at that distance. When it doesn't give you anything tangable at 35 yds in terms of penetration, or killing power, the effort is wasted money, IMO!