Bell of Africa did well on elephant with the 6.5 x 54 but later said with their changed habits, he would prefer a 375 H&H. I have a Searcy 470 double which would be my choice. That is only, of course, because I do not have a 45-70 ;-) But with deer, I am as confident with my 6mm Rem as my 300 W'by. One must be realistic or one may be dead.