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Yes - the longer monometal bullets will require faster powders taking up less space.
There should, however be no problem in achieving "book" speeds.
In 1912, the ballistics were: 2,600fps for 270gr. and 2,400fps for 300's.
Those are the ballistics, with which the .375 earned it's African all-round game killing reputation.
Yes however modern book velocities are around the 2600fps mark for the 300grain. Modern powders and I am more than happy with these velocities. Like the earlier loads they simply work.
This seems about right, based on what I see with my Sako Kodiak rifle assuming a loss of ~ 50 FPS per inch of (shorter) barrel length. Also, most reloading manuals tend to use 26” test barrels, another factor to contemplate.
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Re: 375H&H mag - load observation