When I lived in Alaska the .30-06 was used by quite few people. They used it to feed their families and used it on the big bears. One fellow even killed a maneating polar bear with his. It was written up in one of the outdoor magazines. Loaded with a premium 200 or 220 it would be my minimum.

That being said the .375 is my go to gun. It whacks animals with authority. I could do it with a .30-06 but prefer the .375.