There is a lot of big and dangerous game that I would rather not take on with a .30-06 but nearly all of it is not in North America (with the exception of the Griz and Polar bears). I've felt for quite some time that the .30-06 is a nearly perfect compromise rifle for large, medium, and small North American big game. Heck, I even hunt coyotes with one and have very good luck. I've been playing with a 9.3X62 as a step up from my 06 and as a replacement for my .338 Winchester Magnum and hope to get to Colorado this fall just to witness for myself how it does with elk. I think the description of dangerous game for most of these threads is dealing with a class of animals that haven't existed in North America for 5,000 to 25,000 years. You've got to go to Africa and Asia for them. And then the .375 comes into its own.