In general terms, yes. But if I had my choice, I'd relegate the '06 to smaller stuff and stick to the 375 as the better all-arounder. After all, the '06 and the 375 almost share the same trajectory out to huntable distances. With the 375, the recoil ain't bad at all. If I get to hunt Grizzly, I'd use the 375 and up just to stop the big boy from getting revenge for getting shot.