The only reason I can come up with for doing so is to say that you've done it. That's not why I personally go hunting. You are better off with a .375, you are legal with a .375, your PH will be happier if you shoot a .375 and when you consider the cost of a DG safari anyway (especially such high-dollar species as lion) the price of a good new or used .375 and attendent proper tuning is immaterial. Just get a .375.