I would rather face a charging Bull with the Lott. I would rather fire from 75-100 yds with a Rigby.
I have a .458 Win mag and a .416 Rigby. Because the .458 is a CZ 550 with a 3.85" mag I can load 500gr bullets to a COL of 3.55" and Barns solids to 3.6"+. This allows me to approach or duplicate Lott velocities ( and why I didn't feel the need to have the gun rechambered). Woodleigh make 350-450gr bullets for the .416Rig.That makes it quite versatile and probably a good alternative to a .375H&H if Buff is on the menu and you are only taking one rifle on your Safari. The .458 at Lott velocities kicks noticeably harder than the Rigby.