I'll go for the 404 Jeffreys. Reason: recoil. Think about the wiplash your neck gets everytime you fire a shot, possible tearing of the retina and how quickly after the shot you will have your riffle back on target.

For the past two months I was struggling to decide between a 416 Rigby and a 404 Jeffreys. After a lot of discussions with my friends at the SA bigbore ass. and watching slow motion videos I decided on the 404Jeffreys. There are very little difference in the balistics.Thats only my opinion.