I guess my only argument with shooting the light weight bullets in the 375 would be in the case of hunting multiple species on the same hunt. That being said, it would seem like a good idea to at least stay at 270 gr. or above, especially since the point of impact would likely be way different between the light weights and the heavier bullets. That being said, the 375 and 416 are much closer in trajectory, although not quite the same. The reason I'm asking, is that I'm trying to decide between my 416 and my 375 Ruger for a cape buffalo/plains game hunt. I would most likely only take 1 gun if I ever get to go.