If they made a 300gr. TSX, I think I'd agree. I see the highest vel. listed for the 350 TSX as being mid 2,600's.

Since the .375 is capable of shooting a 225gr. with as high a BC as the 350 TSX, at a speed of 2,900fps to 3,000fps, the .375's long range capability exceeds that of the .416.

Does anyone use them? I don't know. I have developed my own loads for that 225gr.Spire Point to 2,860fps in my .375/06IMP and with that bullet's 1/16" thick jacket ie: .0625", it should penetrate fairly well.

This site's member 9.3x57, has done some penetration tests with this bullet on his game, steer heads and other paraphernalia and so far, the 225gr. exceeds all expectations & matches much heavier, more common bullets from the same .375H&H and 9.3's(when sized down).

The 225gr. is VERY much flatter shooting than a 270gr. TSX at 2,650fps from this same rifle.

Thus, the .416might come close with a 350gr.TSX- certainly will pen more deeply and maybe it's even close enough in ranges that matter?

However, technically speaking, the .375 is MUCH flatter shooting over ranges that perhaps may or may not be applicable. The 'extra' 350fps to 400fps does work to that advantage if needed. Is it needed?