In my opinion...

If you want to go more than 300gr, you should really make the jump to a .40 calibre.

.416, .404, .400, etc. With 400 or 410 grains, it is a proven killer at any velocity from 2100fps +.

But, if you can't or don't want to upgrade, and you are going to shoot big game; an extra 50gr couldn't hurt.

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