If wanting the larger rounds for a lever gun, look to the M92, I'd think. It might work with the .50 - not sure. Pedersoli or Uberti makes one I think, in .45 Colt or .454 Casull. Homer has one in .45 Colt.
Too bad we can no longer obtain WW680 - it was incredible in my .45 Colt M94 Trapper, however WW296 is what I used on the two elk - I obtained 1,584fps with a 300gr. HP from a 16"bl. There are flies on those 1880's .45/90 Winchester factory ballistics. That was with Ross Seyfried's .44 mag pressure loads for the .45 Colt, measured and written up many years ago in Handloader magazine.
The more I think on it, a .45 ACP in a Marlin or M94 would be a fun gun for carry, slimmed down, stubby barrel, maybe 14" to 16", but a serious right for deer and bear, not for me. A .44/40 would have greater killing potential and it's certainly not a "stopper", in spite of Hollywood.
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