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I am a big fan of the .458 lott caliber. It allows you to shoot the lott as well as the winchester magnum ammo. It also lets you choose from an array of bullets, including the 500 grain for large dangerous game. Ammo availability is always a plus!
As a factory chambering the Lott is a pretty good option these days. I hunt with a .450 Ackley Magnum loaded with 500gr Woodleighs and it has been potent on buffalo, giraffe and eland. Then you can load 300gr bullets when you get home and you have a very nice rifle for hunting at home. Best of luck mate.
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Re: What big bore to go for....