At least one person I've seen has made up to the .700 ne on the savage 210 action. The 12 fh that they made on the same action for exceeds the energy and force of the .700. Plus since regular 12ga rounds are rimmed as well the 210 can be modified to accept the smaller diameter .600 no problem. If you just want to have a gun to play around with, and not a dangerous game rifle that your life might depend on then I see no reason why you shouldn't consider the savage. If you are planning on hunting with it then I would say it would not be impossible with enough time and effort, but the .600 ok would be easier. I'm considering building a .500 ne on the savage action, just because I like the nostalgia of the old nitro express rounds.