I think I would use my bowling ball mortar, loaded with the classic load of 1/4 pound of Fg and a 16lb Brunswick, pearl colored ball. I'm not sure about the exact penetration, velocity or total energy. Using Taylor's "knock out" principal I should be o.k. to go up and finish him off with the .375 after the smoke clears...

If nothing else he will be deafened and if close enough he won't be "wooly" anymore.