We have strayed far from formulas.

Have we essentially established that with large and/or dangerous game and the variety thereof, given the complexity of the reaction of living tissue and what if any vital organ is hit, that there really is no simple math?

That even disregarding recoil and weight of the rifle, and assuming well-constructed bullets:

Bigger (bullet weight, diameter) is better up to some point where additional mass becomes overkill?
Faster is better but perhaps only up to a point where higher velocity becomes even counterproductive?

I guess our ballistics hot stove league is a lot more fun than algebra anyway.