Not sure, but I suspect that the lighter projectiles would perform better. I'd taken some 325gn Hornadys out with me but never had the chance to use them. They are designed for the 45/70 but should work okay at the higher velocities.

I'd used 220gn projectiles in my 375H&H many years ago and these worked well on pigs - this projectile was intended for the 375Win lever action round that was almost popular once.