I think a lot of PHs would probably tell you that the .458 Lott is the better and more versatile weapon anyway, particularly if you use factory ammo.

The velocity achieved by the .460 WBY is beyond impressive, but perhaps also beyond what is practical and useful, making the gun somewhat harder to handle.

I am not a bolt action guy but if you want something "bigger" than a .458 Lott and you need to buy a new rifle to get there, I would probably just go for a CZ in .505 Gibbs. Just my $.02.