.458 Lott will take any animal on earth. So will a .460 Weatherby.

It's up to you. Just how much do you want your shoulder to hurt?

My favorite is the Lott. Where I live (Las Vegas, NV) ammo for the Lott is 50% of the cost of the Weatherby.

I like them both. Currently am shooting a .257 Magnum Weatherby Deluxe MK V which I do love. Little shiny, though.