Which model 460Weatherby? I played with one a few weeks ago (DGR) and came away impressed other than the bolt handle which thoroughly tenderised my trigger finger. This is my 'weakness' when it comes to big bore rifles ... some designs strike me on the finger just under the knuckle.

The inline feed of the Weatherby is in my opinion more reliable than the staggered feed CZ but you lose magazine capacity. Both 458Lott and 460Weatherby are reloading propositions, I'd be tempted by the 460Weatherby as they hold resale much better and when reloaded can be dropped back to 458Lott speeds at super mild pressures.
Cheers...
Con