I used 66 grs. of RL-15 and the absolutly fantastic Woodleigh 350 gr. RN and PPs on buffalo last year in Tanzania, along with the 450 gr. 416 Rem and they are the hammer of Thor on buff..

The PP will penitrate a bit better than the RN but the RN opens up to a larger cross section, I prefer the PP I think...

I believe I was the first to test these bullets on Cape Buffalo...They mushroom perfectly every time..I have shot 9 Buffalo with these bullets and I feel the 350 gr. bullet puts the old 375 in the 416 class, and the 450 gr. 416 rates right up there with the 458 Lott or close enough for goverment work

..

Now if I can just get Geoff to make a flat nose solid, we'll be in the pound seats with the lighter calibers.