I reckon a 50cal or 45 cal ball load like that is a big game crusher.
I'm a big fan of Ed's crazy shotloads and sounds like some like minds posting as well. Smoothbore as rifled will donut the pattern I'd say.
If I knew how I would post a pic of what IED attack 'steelshot' ball bearings do to vehicles at a couple thousand fps...

hey Ed is the gun complete or are you still testing while constructing some parts etc?

Regards,
Karl.