2206H - H4895 - has been a good powder for me in a variety of guns, cast as well as jacketed in the .458 2". .458 Alaskan and .450 Alaskan. Obviously, it works well in 450 Ackely's .416.
Another nice aspect of it, is it can be raised in velocity to include top-end loads.
Heat treated bullets, good high-speed lube like Lyman's moly or LBT Blue and 2,400fps loads are possible at Jacketed accuracy.