Gentlemen,

my vote is "pro Weatherby"

I have a 460 with a detachable muzzle break and a 24" barrel.
I load the ammunition with the cheap Hornady standard 500grs SPRN bullet down to 720 m/s (2360 fps).
Without the muzzle break I flinch within 5 shots, but with the muzzle break attached I can shoot 5 shots of the above mentioned load sitting, with sand bag rest, at 100 meters in a 5" circle (using a 6power scope) and no flinch occurs.

Other Wby´s I own are .224, .240, 7mm, 300 and .375 (not Original Weby, but a modification on a Brno Safari rifle) and I like the posssibility of power if I need it and the load-down opportunity for a weakling-application. Precision of Weatherby rifles is good, normally with adjusted reloads 1" for 3 shots, the 224 better than 1/2" for 5 shots (german Sauer -Weatherby system of ca. 1970).

Negative points are the safety and the magazine capacity, but some stockmaker offer modifications for an enlarged magazine box which holds 4 rounds of 378/416/460 in double-column.

best regards
Rolf