I don't have any 2208 but in earlier years have tried faster powders without success with these 400 grainers. Tried the 63 gr load of 2209 yesterday and no luck, hardly keep them on an A4 sheet of paper at 50m where the 350 grainers with gas checks nearly drop down the same hole. Actually softer to shoot too, the 400's starting to bite in recoil at bit. Not like full power factory stuff but just not as nicer cast load to shoot. Will gas check and go from there.