416 and 460 Weatherby. You will find people ether love them or hate them.
I am of the later.
I am one of the guys that don't beleve high velocity is ideal for big game and will only cause you to fear your hard recoiling rifle.
Just a moment ago I fired 12 rounds of 425 at a mild velocity of 2300fps which makes it very easy to shoot well.
This type of calibre (.40 to 450cal)with a velocity of around 2100 to 2300fps with mild recoil is ideal for a DG rifle use IMO.