It sure depends on what your hunting...I have killed a lot of deer with the 222, 223 and 22-250 and they suck, they blood shoot way to much meat IMO, and one small mistake and you have a bad tracking job on your hands...

A 338 with a 300 gr. Woodleigh or a 375 with a solid or 350 gr. woodleigh will just cut a 40 caliber hole through them and kill them just as fast without the meat waste..Same with a 220 gr. 30-06 or even a 180 gr.

I can take any shot the game offers going away or coming and you must take only broadside shots with light fast calibers..

I think its mostly an ego trip when folks claim the small bores are all thats needed for big game and I have seen these self styled experts wound a lot of game over the years.....