In my .375 I use the Speer 270 gr. BTSP for everything. Works wonders on deer & antelope.

One antelope I shot last season was looking at me. My shot was low & hit her breast bone. It was a gory mess. But the next one was also looking at me & I took her in the chest. Classic shot & it didn't tear up much meat at all.

The bullet works well on deer also. I don't think there is much need to reduce the loads.