Also one has to consider that when you hit heavy bone the the big bores can make a rather dramatic wound channal...

Also on Big animals like Buffalo the big bores make a more dramatic internal wound that the small bores would...

In other words in ain't cut and dried.. With big bores,If you use a tough bullet on antelope and stay off the shoulder then you have very little meat damage and can eat right up to the hole..if you use a soft bullet it can tear hell out of everything, especially if you hit the shoulder....