How many elephants did Harry Manners shoot with the .375H&H?
For a two rifle safari, you could not go wrong with a .375H&H and a .458Win/Lott (or take your class 3 pick) for DG; or a .30-06 and a .375H&H for PG. You will always find ammo and never be under-gunned.
Everyone should have a .375