Klaus:

I have used the 300 Hornady RN Interlock on Af plains game {impala and wildebeest}, whitetail deer and elk here in the USA and on all those it's fine tho I would avoid strongly angled shots on the heavier critters above.

I have also tested it in my media {see that thread} and tho I have no experience with it on DG, I would NOT use it for such. It is a relatively frangible bullet compared to others such as Swifts, etc.

Here are some of the .375 test threads:

.375 First Series + 6.5x55 Rem 140:

http://forums.nitroexpress.com/showflat....c5a76e06629b5b4

.375 Second Series:

http://forums.nitroexpress.com/showflat....c5a76e06629b5b4

350 Grain Woodleigh .375 Test + 6.5x55 140 Nosler:

http://forums.nitroexpress.com/showflat....c5a76e06629b5b4

An interesting project would be to see if the 300 Hornady would shoot to same POI as the Woodleigh, then you'd have a cheap one you could use at the range with no need to change sight setting.

By the way, Robertson recommneds downloading the .375 slightly in his book. That is, to 2350 fps IIRC, for buffalo in specific.