The most of the buffalos and the elefants are hunted in Africa with rifles caliber 375H&H and FMJ or solid bullets !!! My opinion, 375H&H is marginal for big game hunting and oftens you need help from your PH!!! I know the problem because i used calibers between 9,3 and .500 for buffalo hunting in Africa and Asia. Now i use a 460WM with SP bullets for buffalos and a 12,7x70 Schüler or a 577NE with FMJ bullets for elefants!