I guess it depends on what you are hunting. There is a big difference in shooting something that just wants to run away and shooting something that wants to, and will, eat you if you don't take it out with the first or second shot.

I've never heard of a hunter getting mauled, trampled, or killed by a deer if he missed his first shot. If I had the the chance I would use my 458 lott on groundhog!...good practice.

Correct me if I'm wrong but isn't it a law that you can not hunt dangerous game in Africa with anything less than a 375?

Would you feel comfortable taking that 223 up to Alaska and going Grizzly hunting! Just my 2cents.