I-too use the fore-end hole when shooting anything but my varmint rigs. They don't change POI, but all my kickers do if not held as if in a hunting postion. That way, with the left knuckles resting on the front bag, fore-end held snuggly just as if shooting offhand, ther is no POI change between load testing, sighting in and hunting.
; Heh, heh, I-too wish all my practise was at game - unfortunately, only the gopher busting is at animals and usually not more than a couple thousand a season. Good offhand, kneeling and sitting practise, though, with hunting weight rifles.